AestheFill
AestheFill®
Collagen Regeneration Filler
AestheFill® is a collagen-stimulating filler formulated with PDLLA (poly-D,L-lactic acid) as its primary active ingredient.
Unlike hyaluronic acid fillers that provide immediate volume, AestheFill® works by gradually stimulating the body’s own collagen production over time — offering a gentle approach to addressing wrinkles, skin laxity, and changes in skin texture.
※ AFRODE CLINIC operates on a referral basis; however, AestheFill® consultations may be booked without a referral.
※ Results vary by individual.
Mechanism
How It Works
When PDLLA (poly-D,L-lactic acid) microparticles are injected into the dermis, the body’s natural response stimulates fibroblasts to produce collagen. Over approximately 3–4 months, autologous collagen is gradually generated, supporting natural firmness and elasticity from within the skin.
Features
Key Features of AestheFill®
PDLLA
Bioabsorbable Material
PDLLA (poly-D,L-lactic acid) is a highly biocompatible material that gradually breaks down into water and carbon dioxide within the body over time.
COLLAGEN
Autologous Collagen Stimulation
After injection, PDLLA microparticles have been reported to stimulate fibroblasts, promoting the body’s own collagen production.
DURATION
Gradual, Natural-Looking Change
Visible changes immediately after treatment are minimal; results develop gradually over 3–4 months. ※ Individual results and duration may vary.
For Whom
Who May Benefit from This Treatment
Those who wish to proactively address early signs of facial aging
Those beginning to notice a decline in skin firmness and elasticity
Those who have reservations about repeated hyaluronic acid injections
Those seeking gradual, subtle improvement rather than dramatic reshaping
※ Suitability for treatment is determined following a physician consultation. Not all individuals may be eligible.
Side Effects & Risks
Potential Side Effects & Risks
The following side effects and risks have been reported in association with this injectable treatment. Our physician will explain all details in full prior to the procedure.
- Swelling, redness, bruising, and discomfort at the injection site (typically resolving within a few days to two weeks)
- Pain, tenderness, or itching
- Nodules or lumps (rare; reported at approximately 0.04%, or 6 cases in 16,000 in international data)
- Asymmetry, surface irregularity, or granuloma formation
- Infection (a general risk associated with injectable procedures)
- Allergic reaction
- In very rare cases, vascular occlusion leading to skin injury or visual disturbance
※ The above is a summary of key risks and is not exhaustive. Full details will be discussed by the attending physician at your consultation.
Pricing
Pricing (Tax Included)
| Treatment Area | Price (Tax Incl.) |
|---|---|
| Nasolabial folds | ¥110,000 |
| Tear trough / Cheek grooves | ¥79,200 |
| Eye area | ¥78,100 |
※ Detailed pricing will be provided at your consultation.
Doctor
Attending Physician
Dr. Shotaro Michishita (Director, AFRODE CLINIC)
2015 — Graduated from The Jikei University School of Medicine
2017 — Joined the Department of Neurosurgery, Jikei University Hospital
2021 — Left the department; began supervising AFRODE CLINIC
AestheFill® Certified Training Physician
Evidence
References
- Hyun MY, Lee Y, No YA, Yoo KH, Kim MN, Hong CK, et al. Efficacy and safety of injection with poly-L-lactic acid compared with hyaluronic acid for correction of nasolabial fold: a randomized, evaluator-blinded, comparative study. Clin Exp Dermatol 2015 Mar;40(2):129-135.
- Qiao J, Jia QN, Jin HZ, Li F, He CX, Yang J, et al. Long-Term Follow-Up of Longevity and Diffusion Pattern of Hyaluronic Acid in Nasolabial Fold Correction through High-Frequency Ultrasound. Plast Reconstr Surg 2019 Aug;144(2):189e-196e.
Book a Consultation
AestheFill® appointments may be booked without a referral.
A physician consultation is required prior to any treatment.
Please feel free to contact us with any questions in advance.